|
T25268 |
Coblopasvir
|
|
Others
|
|
Coblopasvir is a pan-genotypic non-structural protein 5A (NS5A) inhibitor. It can be used to study chronic hepatitis C virus infection. |
|
T4197 |
HZ-1157
|
HZ1157,DHFR-inhibitor |
HCV Protease
|
|
HZ-1157 (DHFR-inhibitor) is a hepatitis C virus (HCV) inhibitor with inhibitory activities toward HCV NS3/4A protease. |
|
T5126 |
Glecaprevir
|
ABT-493 |
HCV Protease
,
SARS-CoV
|
|
Glecaprevir (ABT-493) is an HCV NS3/4A protease inhibitor, (IC50s: 3.5-11.3 nM). |
|
T1822 |
Clemizole
|
|
HCV Protease
,
Histamine Receptor
|
|
Clemizole is an H1 histamine receptor antagonist, can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication. |
|
T4547 |
Grazoprevir
|
MK-5172 |
HCV Protease
,
SARS-CoV
|
|
Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Ki of 0.01 nM (gt1a), 0.08 nM (gt2a), 0.90 nM (gt3a), 0.01 nM (gt1b), ... |
|
T19862 |
Voxilaprevir
|
|
HCV Protease
|
|
Voxilaprevir is an inhibitor of hepatitis C virus (HCV) nonstructural (NS) protein 3/4A protease. |
|
T4474 |
Asunaprevir
|
BMS-650032 |
HCV Protease
,
SARS-CoV
|
|
Asunaprevir (BMS-650032) is an effective hepatitis C virus (HCV) NS3 protease inhibitor. |
|
T1822L |
Clemizole hydrochloride
|
|
HCV Protease
,
Histamine Receptor
|
|
Clemizole hydrochloride is an antagonist for H1 histamine receptor. According to the research, Clemizole hydrochloride can inhibit hepatitis C virus (HCV) replication and NS4B's RNA binding. |
|
T25268L |
Coblopasvir dihydrochloride
|
Coblopasvir dihydrochloride(1312608-46-0 Free base) |
HCV Protease
|
|
Coblopasvir dihydrochloride can be used to study chronic HCV infection and is a pan-genotypic nonstructural protein 5A (NS5A) inhibitor. |
|
T9567 |
Samatasvir
|
ATOLIHZIXHZSBA-BTSKBWHGSA-N,IDX719 |
HCV Protease
|
|
Samatasvir (ATOLIHZIXHZSBA-BTSKBWHGSA-N) is a pan-genotypic inhibitor of the HCV non-structural protein 5A. |
|
T4988 |
Boceprevir
|
SCH 503034,EBP 520 |
HCV Protease
,
SARS-CoV
|
|
Boceprevir (SCH 503034) is a novel, potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with Ki of 14 nM in both enzyme assay and EC90 of 350 nM in cell-based replicon assay. |
|
T22394 |
Paritaprevir
|
ABT450,ABT-450,Veruprevir |
HCV Protease
|
|
Paritaprevir (ABT450) is an inhibitor of non-structural protein 3/4A protease with EC50 values of 1 and 0.21 nM for HCV 1a and HCV 1b, respectively. |
|
T6190 |
Telaprevir
|
VX-950,LY-570310,Incivek,MP-424 |
HCV Protease
,
SARS-CoV
|
|
Telaprevir (Incivek) (VX-950) is an effective inhibitor of HCV NS3-4A serine protease (IC50: 0.35 μM). |
|
T4686 |
Simeprevir
|
TMC435,TMC-435350,Olysio |
HCV Protease
,
SARS-CoV
|
|
Simeprevir (TMC435) is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM. |
|
T6025 |
Danoprevir
|
R7227,ITMN-191,RG7227,RO5190591 |
HCV Protease
,
SARS-CoV
|
|
Danoprevir (RG7227) is a peptidomimetic inhibitor of the NS3/4A protease(IC50=0.2-3.5 nM) of hepatitis C virus (HCV). |
|
T28830 |
Sovaprevir
|
ACH 0141625,ACH0141625,ACH-0141625,ACH1625,ACH 1625,ACH-1625 |
HCV Protease
|
|
Sovaprevir is a non-structural 3 (NS3) protease inhibitor with antiviral activity for the treatment of HCV infection. |
|
T3226 |
Paritaprevir
|
ABT-450,Veruprevir |
HCV Protease
|
|
Paritaprevir (ABT-450) is an orally bioavailable, synthetic acylsulfonamide inhibitor of the hepatitis C virus (HCV) protease complex comprised of non-structural protein 3 and 4A (NS3/NS4A), with potential activity again... |
|
T14555 |
BI-1230
|
|
HCV Protease
|
|
BI-1230 is a potent inhibitor of HCV NS3 protease, exhibiting efficacy in the low nanomolar range, and notably suppresses viral replication. This compound demonstrates high selectivity, distinguishing effectively between... |
|
T71131 |
IDX-320
|
|
|
|
IDX-320 is an HCV protease inhibitor. |
|
T35043 |
Vedroprevir
|
GS9451,GS 9451,GS-9451 |
|
|
Vedroprevir, also known as GS9451, is a selective hepatitis C virus (HCV) NS3 protease inhibitor in the development of the treatment of genotype 1 (GT1) HCV infection. |
|
T10535 |
BI 653048
|
|
P450
|
|
BI 653048 is a selective and orally active agonist of nonsteroidal glucocorticoid (IC50: 55 nM). BI 653048 is also an HCV NS3 protease inhibitor. |
|
T71006 |
BI-1388
|
|
|
|
BI-1388 is a highly potent inhibitor of HCV NS3 protease activity, inhibiting viral replication for various HCV genotypes and for resistant mutants D168V and R155K. |
|
T71215 |
Faldaprevir sodium
|
|
|
|
Faldaprevir sodium is a potent NS3/NS4A protease inhibitor potentially for the treatment of HCV infection. Faldaprevir is known to inhibit P-glycoprotein, CYP3A4, and UDP-glucuronosyltransferase 1A1. |
|
T71653 |
GS-9256
|
|
HCV Protease
|
|
GS-9256 is a selective inhibitor of the HCV NS3 protease, exhibiting favorable pharmacokinetic properties and antiviral activity [1]. |
|
T19685 |
Faldaprevir
|
BI-201335,BI201335,BI 201335 |
|
|
Faldaprevir is an effective NS3/NS4A protease inhibitor potentially for the treatment of HCV infection. Faldaprevir is known to inhibit P-glycoprotein, CYP3A4, and UDP-glucuronosyltransferase 1A1. |
|
T39503 |
Hepatitis Virus C NS3 Protease Inhibitor 2
|
|
|
|
Hepatitis Virus C NS3 Protease Inhibitor 2 is a peptide inhibitor derived from a product that targets the NS3 protease of the hepatitis C virus (HCV). Its inhibitory activity against the NS3 protease is characterized by ... |
|
T76521 |
HCV NS4A Protein (18-40) (JT strain)
|
|
|
|
HCV NS4A Protein (18-40) (JT strain) is a peptide derived from residues 18 to 40 of the HCV NS4A protein. It enhances the catalytic efficiency of NS3 protease [1]. |
|
T76525 |
Ac-EEVVAC-pNA
|
|
|
|
Ac-EEVVAC-pNA serves as a chromogenic substrate specifically designed for the continuous spectrophotometric assay of the HCV NS3 protease. Its sequence, EEVVAC, originates from the 5A-5B cleavage junction within the HCV ... |
|
T19627 |
Ciluprevir
|
BILN 2061ZW,BILN 2061,BILN-2061ZW,BILN-2061,BILN2061ZW,BILN2061 |
|
|
Ciluprevir is an effective and selective HCV NS3 protease inhibitor with proven antiviral effect in humans. Ciluprevir may be an antiviral agent for individuals infected with non-genotype-1 HCV. In vitro sensitivity stud... |
|
T76524 |
Hepatitis C Virus S5A/5B
|
|
|
|
Hepatitis C Virus S5A/5B, a synthetic peptide substrate, replicates the NS5A/5B junction of the nonstructural protein (NS), serving as the substrate for examining HCV NS3 protease activity [1]. |
|
T76526 |
Ac-D-DGla-LI-Cha-C
|
|
|
|
Ac-D-DGla-LI-Cha-C is a potent peptide inhibitor of the HCV protease, applicable in research targeting a range of diseases, including cancer, autoimmune, fibrotic, inflammatory, neurodegenerative, infectious, lung, heart... |
|
T73898 |
Paritaprevir dihydrate
|
|
|
|
Paritaprevir dihydrate (ABT-450), a highly effective and orally administered antiviral, acts as a non-structural protein 3/4A (NS3/4A) protease inhibitor, displaying EC50 values of 1 and 0.21 nM against HCV genotypes 1a ... |
